Clinical Trials of Scallop-derived PLASMALOGEN
Summary of Research & Development of plasmalogen by Japan’s research team chaired by Takehiko Fujino, Emeritus Professor of Kyushu University:
Clinical effectiveness of Scallop-derived PLASMALOGEN on dementia (mild Alzheimer’s disease) patients:
In a clinical trial, patients (aged 60 – 85 years) with mild Alzheimer’s disease (AD) were orally administered 1,000 µg (500 µg twice a day)* Scallop-derived PLASMALOGEN or placebo daily for 24 weeks and their cognitive function was assessed.
Oral administration of Scallop-derived PLASMALOGEN significantly improved memory function of the mild AD patients in which significant memory improvement was also seen in a subgroup of female subjects and those who were younger than 77 years old. No clinically relevant adverse events were observed and thus, it is safe for consumption.
Scallop-derived PLASMALOGEN improves cognitive function of mild Alzheimer’s disease (AD) patients
Mild AD patients
Female mild AD patients
Mild AD patients aged 77 or younger
EBioMedicine 17: 199-205 (2017)
Open clinical trial of Scallop-derived PLASMALOGEN on patients with moderate and severe dementia:
Title of this trial: Effect of plasmalogen-containing food on cognitive function in patients with dementia (except mild Alzheimer’s disease)
Patients with moderate and severe dementia (Alzheimer’s dementia, Lewy body dementia, cerebrovascular dementia and semantic dementia) were the targeted subjects in this open trial. To compare the effects of the ingestion of Scallop-derived PLASMALOGEN, evaluation of MMSE scores of the subjects, objective evaluation by caregivers and measurement of blood plasmalogen concentration were performed for a period of 3 months. This trial involved 225 Japanese men and women aged 60 to 85. This trial had been completed in April 2016 and the data is expected to be available in recent years.
Who should take Scallop-derived PLASMALOGEN…
Alzheimer’s disease is a progressive disease, which could be detected at an early stage by consulting a physician. Early discovery helps individuals and family members to have a better understanding of the symptoms and sufficient time for future planning. Appropriate timely actions can possibly delay the onset of the disease and improve symptoms. High-purity Scallop-derived PLASMALOGEN is suitable for people:
- experiencing signs and symptoms of Alzheimer’s disease.
- whom are concern with forgetfulness on recent events.
- with family members whom are displaying symptoms of dementia.
- experiencing lifestyle-related diseases, such as diabetes and high blood pressure.
Take Scallop-derived PLASMALOGEN as early as possible…
The development of orally bio-available Scallop-derived PLASMALOGEN provides new hope in replenishing low plasmalogen levels and restoring cognitive functions in Alzheimer’s patients. As changes in the brain sets in 20 years prior to surfacing of symptoms of Alzheimer’s disease, it is important to take Scallop-derived PLASMALOGEN as early as possible as it may be more beneficial in reducing the risk of Alzheimer’s disease. In addition, greater percentage of moderate dementia patients responded better and showed cognitive improvement after taking Scallop-derived PLASMALOGEN compared patients with severe dementia. Evidences show that intake of Scallop-derived PLASMALOGEN is most beneficial for patients upon diagnosis in improving long term treatment outcome.